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AUTOIMMUNE DISEASES
Targeting the PI3K Delta is a novel approach for the treatment of inflammatory disorders such as asthma, chronic obstructive pulmonary disease and rheumatoid arthritis.
Rheumatoid Arthritis
Inhibition of PI3K Delta reduces B cell auto-antibody production, macrophage invasion, and pro-inflammatory cytokines. With a direct effect on macrophages and RA synovial fibroblasts, joint inflammation is dampened.